Preimplantation Genetic Testing (PGT) is a genetic screening procedure used during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to examine embryos for specific genetic abnormalities before they are implanted in the uterus. The primary purpose of PGT is to ensure that only genetically healthy embryos are selected for implantation, thereby increasing the chances of a successful pregnancy and reducing the risk of passing on inherited genetic disorders. PGT is particularly recommended for couples with a history of hereditary diseases or those undergoing assisted reproductive techniques due to infertility, where the risk of genetic abnormalities is higher.
PGT involves taking a small number of cells from an embryo at the blastocyst stage (usually on day 5 or 6 of development) and analyzing them in the laboratory. At Genetiks, we utilize advanced technologies like NGS to thoroughly examine embryos, screening for conditions like thalassemia, cystic fibrosis, and SMA, and determining the HLA compatibility.
There are different types of PGT, each serving a specific purpose:
There are three types of PGT:
- PGT-A (Aneuploidy): Screens for abnormal numbers of chromosomes, preventing conditions like Down syndrome and reducing the risk of miscarriage.
- PGT-SR (Structural Rearrangements): Identifies structural chromosome rearrangements, such as translocations, that may lead to infertility or genetic disorders.
- PGT-M (Monogenic Disorders): Detects single-gene disorders such as cystic fibrosis, thalassemia, or Huntington's disease.
More info @ https://pgt.genetiks.com.tr