BioER & MicroVE
BioER and MicroVE from Bioarray are advanced tests designed to optimize implantation success rates by assessing the receptivity of the endometrium. The bioER test analyzes key gene transcriptional activity to determine the optimal window of implantation, ensuring that the endometrium is most receptive. The MicroVE test complements this by evaluating the microbiota of the endometrium, identifying microbial imbalances that could affect implantation. Together, these tests provide a comprehensive approach to enhancing fertility outcomes.
BioER: Endometrial Receptivity Test
Endometrial receptivity tests are designed to determine the optimal timing for embryo transfer during IVF, thereby increasing the chances of a successful pregnancy. These tests focus on identifying the Window of Implantation (WOI), which is a critical period when the endometrial lining of the uterus is most receptive to an embryo. Typically, this window occurs around 6-10 days after ovulation, but it can vary among individuals.
By analyzing the genetic expression profiles of the endometrium, these tests help to pinpoint the precise timing of the WOI. The test results can indicate whether the endometrium is pre-receptive (too early for implantation), receptive (optimal time for embryo transfer), or post-receptive (too late for implantation).
Depending on the results:
- Pre-receptive: If the test shows that the endometrium is not yet receptive, the embryo transfer can be delayed to align with the WOI.
- Receptive: If the endometrium is receptive, the transfer can proceed, maximizing the chances of successful implantation.
- Post-receptive: If the window has passed, the timing of embryo transfer may need to be adjusted in future cycles to match the WOI.
Understanding and aligning with the WOI through these tests can significantly improve IVF success rates by ensuring that the embryo is transferred at the most receptive time.
MicroVE: Test for Endometrial Microbiota
The MicroVE test is a specialized diagnostic tool that analyzes the microbiota of the endometrium, focusing on the presence and balance of various bacterial species, particularly Lactobacillus. The endometrial microbiome plays a crucial role in maintaining a healthy uterine environment, which is essential for successful embryo implantation and pregnancy.
A healthy endometrium is typically dominated by Lactobacillus species, which create an acidic environment that acts as a protective barrier against harmful pathogens. When the balance of the microbiota is disrupted, conditions such as bacterial vaginosis or other dysbiotic states can occur, leading to a less favorable environment for embryo implantation.
The MicroVE test provides detailed information about the microbial composition of the endometrium, including the levels of Lactobacillus and the presence of potentially harmful bacteria. Based on the test results:
- High Lactobacillus Dominance: Indicates a healthy microbiome, optimal for embryo implantation and pregnancy.
- Low Lactobacillus Levels: Suggests a dysbiotic state, which may require probiotic treatment or antibiotics to restore balance before proceeding with embryo transfer.
- Presence of Pathogenic Bacteria: Identifies the need for targeted antimicrobial treatment to eliminate harmful bacteria and improve the chances of a successful pregnancy.
By understanding the specific microbial environment of the endometrium, the MicroVE test allows for personalized interventions aimed at optimizing the conditions for embryo implantation, thus enhancing the success rates of IVF treatments.