Y-Chromosome Microdeletion Test
The Y-Chromosome Microdeletion Test is a critical molecular genetic test used to determine the underlying causes of male infertility. There is a strong correlation between microdeletions on the Y chromosome and infertility. For example, microdeletions in the AZF regions are found in approximately 15% of non-obstructive azoospermia cases and in 5-10% of severe oligospermia cases.
The AZF regions are located on the long arm of the Y chromosome and contain crucial genes involved in sperm production. Deletions in these regions can lead to varying degrees of sperm production defects, impacting fertility.
By identifying these microdeletions, the Y-Chromosome Microdeletion Test can provide valuable insights for diagnosing male infertility and guiding appropriate treatment strategies.
